Homing of in Vitro Expanded Stro-1 or Stro-1 Human Mesenchymal Stem Cells into the Nod/scid Mouse. Their Role in Supporting Human Cd34 Cell Engraftment
نویسندگان
چکیده
M. BENSIDHOUM, A. CHAPEL, S. FRANCOIS ,C. DEMARQUAY, C. MAZURIER, L. FOUILLARD, S. BOUCHET, JM. BERTHO, P. GOURMELON, J. AIGUEPERSE, P. CHARBORD, NC. GORIN, D. THIERRY, M. LOPEZ (1) : Laboratoire de Thérapie Cellulaire et de Radioprotection Accidentelle, Faculté de Médecine Saint Antoine et IRSN, EA 1638 et Inserm U76.– (2) : Institut de Radioprotection et de Sureté Nucléaire, Fontenay Aux Roses – (3) : Laboratoire d’Hématopoïèse, Faculté de Médecine, Tours, France.
منابع مشابه
Homing of in vitro expanded Stro-1- or Stro-1+ human mesenchymal stem cells into the NOD/SCID mouse and their role in supporting human CD34 cell engraftment.
The Stro-1 antigen potentially defines a mesenchymal stem cell (MSC) progenitor subset. We here report on the role of human ex vivo-expanded selected Stro-1(+) or Stro-1(-) MSC subsets on the engraftment of human CD34(+) cord blood cells in the nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mouse model. The data show that cotransplantation of expanded Stro-1(-) cells with CD34(+)...
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Clinical applications of mesenchymal stem cells (MSCs) rely on their capacity to home and engraft in the appropriate target tissues for a long time. Homing and engraftment capacity of these stem cells depend on the expression of Chemokines and their receptors. Ex vivo expanded MSCs exhibit homing potential when grafted to injury tissue but their homing efficiency has been observed very poor bec...
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